The RNA Printer® is CureVac’s integrated and automated manufacturing solution for RNA vaccines and therapeutics. CureVac RNA Printer GmbH to provide dedicated infrastructure to accelerate development and broaden application range of The RNA Printer®. Dr. Markus Bergmann appointed as General Manager for CureVac RNA Printer GmbH.

In the field of optogenetics, scientists investigate the activity of neurons in the brain using light. A team led by Prof. Dr. Ilka Diester and Dr. David Eriksson from the Optophysiology Laboratory at the University of Freiburg has developed a new method to simultaneously conduct laminar recordings, multifiber stimulations, 3D optogenetic stimulation, connectivity inference, and behavioral quantification on brains.

Macrophages interacting with cytomegaloviruses - 22/02/2022

Cytomegaloviruses subvert macrophage identity

Cytomegaloviruses are basically harmless. However, if they occur along with other pathogens, they can trigger serious diseases. They can manipulate our immune system and encourage resident defence cells to migrate. Researchers at the Centre for Chronic Immunodeficiency (CCI) at the Freiburg University Medical Centre have discovered which mechanisms underlie the behavioural changes in macrophages that make it easier for other pathogens to attack.

Natural fibers in use - 15/02/2022

Sustainable reinforcement of e-bike battery cases

Ansmann AG from Assamstadt provides mobile energy solutions with a focus on sustainability. The BioBattery project, which was awarded the Baden-Württemberg Bioeconomy Innovation Prize, saw Ansmann AG working with the Fraunhofer LBF in Darmstadt to develop a natural fibre reinforced plastic composite for use in e-bike battery cases.

CureVac N.V. (Nasdaq: CVAC), a global biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid (“mRNA”), today announced that it has dosed the first participant in a Phase 1 study of its seasonal influenza second-generation mRNA vaccine candidate, CVSQIV, developed in collaboration with GSK.

The annual highlight of the industry is the International Conference on Cellulose Fibres in Cologne (www.cellulose-fibres.eu), where the latest innovations were showcased last week: new cellulose fibre technologies for various feedstocks and a wide range of hygiene and textile products as well as alternatives to plastics and carbon fibre for lightweight constructions.

The European Research Council is funding a large-scale proof-of-concept study on a new genome sequencing method called “Haplotagging”. Haplotagging is a new method for sequencing our genome with superior quality and faster speed, developed by group leader Frank Chan and his team at the Friedrich Miescher Laboratory at the Max Planck Campus, Tübingen, Germany.

5G-OR is one of the 4 winning projects jointly selected by the Federal Ministry of Economics and Climate Action in Germany and the Ministry of Economy, Finance and Relaunch in France for the call “Technical developments and application ecosystems for 5G private networks”. The joint Franco-German 5G-OR project takes up the challenge in the healthcare domain.

fischertechnik has set a new milestone with the Animal Friends construction kit, as the building blocks and packaging are largely made of renewable resources and the models depict playful animals in new colours. The company is thereby taking another major step towards sustainability. The bio-based building set recently won the Toy Award, one of the most prestigious awards in the industry.

Biosensor for whole blood and exhaled breath analysis - 02/02/2022

Antibiotic detection from whole blood or exhaled breath possible

Incorrectly dosed antibiotics are not only dangerous for patients, but also often the cause of resistant strains of bacteria. Researchers at the University of Freiburg have developed a biosensor to determine the effective amount and thus enable personalised therapy. The biosensor works by rapidly determining small amounts of the substances directly from whole blood or exhaled breath.

Researchers use epigenetic factors to investigate the role of stress in the development of tumor diseases. Experts believe that stress plays a major role in the development of tumors. One occupational group, for example, that experiences extreme stress over a short period of time is astronauts.

Drugs consist of molecules developed in the drug laboratory that bind to their target, usually a protein, and thus exert their effect. The actual duration of binding of a drug molecule to its target protein varies depending on the drug. The lifetime of the drug-target complex can play a critical role in the efficacy of a drug, as a long residence time at the target can be crucial for the drug's action in some cases.

Dr. Stefan Schiller and Dr. Matthias Huber from the University of Freiburg’s livMatS Cluster of Excellence have succeeded in developing a muscle solely on the basis of natural proteins. The autonomous contractions of the material, which the researchers presented in the journal Advanced Intelligent Systems, can be controlled with the help of pH and temperature changes.

Viral zoonoses - 24/01/2022

Development of inhibitors that help stop viral zoonoses

Emerging viral infections such as COVID-19 or Zika disease pose an increasing threat to humans. At the Institute of Pharmacy and Molecular Biotechnology (IPMB) at Heidelberg University, Prof. Dr. Christian Klein's research group is developing inhibitors against already known viruses in the hope that these can also be used against new virus variants.

The HUEHOCO GROUP Holding GmbH & Co. KG, a family-owned company from Wuppertal, North Rhine-Westphalia, has acquired a 5 percent stake in carbonauten GmbH. The start-up is in negotiations with further interested parties from Germany and Japan. With the international metal strip refiner HUEHOCO Group, which has sites on 4 continents, the "minus CO2 factory" has acquired its first industrial partner.

microRNA as a prognostic biomarker - 13/01/2022

Heart attack diagnosis: fast and unambiguous thanks to artificial intelligence

People that arrive in emergency rooms with chest pain require swift action in order to rule out a heart attack or to initiate vital life-saving therapy. However, despite many advances, current tests are not yet optimal: they either take hours or produce false-positive results. Researchers at Heidelberg University Hospital are now using AI in an approach that takes microRNAs from a blood sample to specifically diagnose ‘acute coronary syndrome’.

Making important raw materials for fine chemicals out of carbon dioxide really works. As part of the Max Planck collaborative project eBioCO2n, a team of researchers from Fraunhofer IGB have successfully performed a first ever fixation of CO2 via a multi-enzyme enzyme reaction driven by electricity yielding a prospective intermediate for the chemical industry. The process for electro-biocatalytic CO2 fixation was recently published and is…

Protection against game damage - 13/01/2022

Sapling protectors made of domestic wood - simple but effective

Young forest plants need protecting against damage and as a result it’s often hard to miss the colourful plastic tree guard sleeves when out walking in forests. These tree guard sleeves are neither pleasing to the eye nor sustainable. Bernd Schairer UG from Albstadt has developed sapling protectors made of wood that contain no plastics, metals or chemicals, do not require removal and disposal, and are produced in a socially responsible way.

Chitin is the main component of insect carapaces and ensures that they are both stable and flexible. The Chitinfluid research project, funded by the Carl Zeiss Foundation, focuses on the use of chitin in construction and aims to process chitin and its derivatives into sustainable materials. In a hybrid symposium under the auspices of Prof. Sabine Laschat from the University of Stuttgart, the project team discussed the current state of research…

The incidence of colorectal cancers in young adults is increasing. At the same time, the proportion of overweight and obese young people is also on the rise. Whether there is a connection between these two observations, however, was not known until now. Scientists at the DKFZ have now shown that the risk of early colorectal cancer is significantly increased in overweight young people compared to normal-weight peers.

Genetic alterations that promote the development and spread of tumors are difficult to identify. This is especially true for mutations in the non-protein-coding regions of the genome, which include all important regulatory sequences. Scientists at the German Cancer Research Center have now published an algorithm that detects cancer drivers in both the protein-coding and non-coding regions of the genome.